U.S. Apologizes For Syphilis Experiments In Guatemala

Mercer 10827


Guatemala's President Alvaro Colom holds a press conference on Oct. 1, 2010 describing the U.S.-led experimentation of the effects of syphilis on Guatemalan citizens without their consent as 'crimes of lese-humanity.'

A professor reveals a 64-year-old government-funded study in which subjects were deliberately infected and then treated with penicillin. But it is unclear whether they were cured.

There's no statute of limitations on the violation of human rights in medical research, the U.S. government acknowledged Friday.

Secretary of State Hillary Clinton and Health and Human Services Secretary Kathleen Sebelius apologized for a U.S.-funded study that led to the deliberate infection of hundreds of Guatemalans with syphilis from 1946-1948.

"Although these events occurred more than 64 years ago, we are outraged that such reprehensible research could have occurred under the guise of public health," their statement reads.

The study in Guatemala was undertaken to investigate the use of penicillin to treat and prevent syphilis infection, but the results were never published. Wellesley professor Susan M. Reverby uncovered documents about the work in an archive at the University of Pittsburgh.

The researchers infected nearly 700 prisoners and mental patients in Guatemala with syphilis. Prostitutes with syphilis were used to infect male prisoners. The researchers deceived the study subjects about the experiment and concealed the facts of their infection.

The study subjects were treated with penicillin afterward, but Reverby writes that it's unclear whether they were cured. Some didn't get what would have been considered adequate doses of the antibiotic.

Dr. John Cutler, a doctor with the U.S. Public Health Service who also took part in the infamous Tuskegee syphilis study, led the work in Guatemala, according to Reverby. The Guatemala study was sponsored by the Public Health Service, the Pan American Health Sanitary Bureau (a forerunner of the Pan American Health Organization), the Guatemalan government and the National Institutes of Health.

In a media briefing Friday, NIH Director Dr. Francis Collins said, "I find it very difficult as a physician-researcher today [to imagine] that the participants in them could have considered them ethical" even in the 1940s. Research standards were less well-developed then.

The revelations could further set back the participation of minority subjects in clinical research. Once again, Collins said, there is another example "of medical research being conducted on vulnerable populations in a way that is reprehensible."

He praised Reverby, however, saying she "has done a good thing here by uncovering aspects of a study that was previously unknown."

Ethical standards and government oversight would prevent these problems from happening today, Collins said.

Collins said the government has asked the National Institute of Medicine to conduct a fact-finding investigation of the Guatemalan study. A separate assessment will be done by the Presidential Commission for the Study of Bioethical Issues. Copyright 2010 National Public Radio. To see more, visit http://www.npr.org/.

More in U.S. / World


blog comments powered by Disqus