Two more senators have added their names to the list of "no" votes on a motion to bring the Republican plan to replace Obamacare to the floor, ensuring that it doesn't have enough support.
Utah Republican Mike Lee and Jerry Moran of Kansas have added their names to the "no" column, joining the entire Democratic caucus.
"We must now start fresh with an open legislative process to develop innovative solutions that provide greater personal choice, protections for pre-existing conditions, increased access and lower overall costs for Kansans," Moran said in a statement.
Previously, Sens. Rand Paul of Kentucky and Susan Collins of Maine had said they would vote not to support the Better Care Reconciliation Act (BCRA), which was to be the latest Republican attempt to replace the Obama administration's Affordable Care Act.
With Democrats against the measure, it could only afford to lose the support of two Republicans.
Sen. John McCain, who underwent surgery on Saturday, has not said how he would vote.
As NPR's Geoff Bennett and Tamara Keith reported earlier this week, Senate Republicans, realizing how close the vote was, had delayed taking up the measure until McCain was well enough to return to the Senate.
They wrote: "McConnell had been in a rush to get the bill to a vote, in part because it was thought more time wouldn't help and could hurt the chance for passage."
In a statement released shortly after Lee and Moran made their announcement, New York Sen. Charles Schumer said the "second failure of Trumpcare is proof positive" that the bill is "unworkable."
"Rather than repeating the same failed, partisan process yet again, Republicans should start from scratch and work with Democrats on a bill that lowers premiums, provides long term stability to the markets and improves our health care system," Schumer said.
Meanwhile, Sen. Lindsey Graham of South Carolina, touted his own version of the bill announced last week: