Health

Why Hoarding Of Hydroxychloroquine Needs To Stop

Transmission electron micrograph of particles of SARS-CoV-2 — the coronavirus that causes COVID-19.
Transmission electron micrograph of particles of SARS-CoV-2 — the coronavirus that causes COVID-19.
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A family of old antimalarial drugs — including one that some patients rely on to treat their lupus or rheumatoid arthritis — is becoming harder to get in the United States, pharmacists say, partly because of remarks President Trump made last week, highlighting the drugs as a potential treatment for COVID-19.

"I feel good about it. That's all it is, just a feeling," President Trump said during a White House briefing Thursday about chloroquine and hydroxychloroquine. "You're going to see soon enough."

Health officials were quick to warn that enthusiasm for such a treatment is premature. Big clinical studies of the drugs against COVID-19 have only just begun, the head of the Food and Drug Administration said. There are some reasons to think cell studies that look promising in the lab won't pan out in real patients, others say.

Nonetheless, with all the buzz, U.S. pharmacists are concerned about hoarding of the drug by people who don't have an immediate need.

Dentists and doctors writing prescriptions for themselves

"Our members are definitely seeing more demand for this medication and possibly some people trying to hoard the medication," says Todd Brown, executive director of the Massachusetts Independent Pharmacists Association.

According to Brown, it appears the hoarders include doctors and dentists who are writing prescriptions for themselves or family members.

"Pharmacists are seeing an increase in requests and prescriptions for them, in instances where it's not clear why the patient needs it at this time," he says.

Brown is suggesting that pharmacists restrict prescription quantities and only fill prescriptions for patients with an active need for hydroxychloroquine.

In a statement, CVS Health says the company is "monitoring the global pharmaceutical manufacturing environment and working with our suppliers to ensure we can continue filling prescriptions for our pharmacy patients and plan members."

CVS says it has an adequate supply of hydroxychloroquine and is taking steps to make sure the supply remains stable. Some data show hospitals stocking up on the drug, as well.

State pharmacy boards put the brakes on prescriptions

The National Association of Boards of Pharmacy says six states, so far, have taken steps to limit inappropriate prescriptions for hydroxychloroquine and preserve supplies for patients who take the medicine as approved. Those states are Texas, Louisiana, Ohio, North Carolina, Nevada and Idaho.

"Based on reports we see from the states, pharmacists have a fairly good idea that what they're seeing is prescribers prescribing for themselves and their families and stockpiling these medications rather than prescribing for patients," says Carmen Catizone, the executive director of NABP.

If doctors are hoarding, some colleagues say that's unethical. Dr. Michael Barnett, a primary care physician and assistant professor at the Harvard T.H. Chan School of Public Health, says that even if the drug turns out, from the clinical studies now in progress, to be effective against COVID-19,, it must be saved for those most in need.

"There are front-line physicians where, if this medication is actually effective or can be used to prevent coronavirus, they certainly could merit treatment with that," Barnett says. And, he notes,"we are very far from knowing whether it's effective in that manner. "

Still, Barnett says he can see why a doctor or nurse might say, "Hey, I can't get the masks or goggles or gowns I need to protect myself, why not try this medication?"

Need a stable supply for non-COVID-19 patients

Barnett is sympathetic, but he points out this powerful medicine has serious side effects, so it should not be taken unless there's a known benefit.

"Having sort of a free-for-all in terms of prescribing for oneself and just deciding that 'I'm going to grab some while I can,' is the kind of mentality that can really undermine our efforts to actually have a concerted public health campaign against this disease," Barnett says.

More immediately, there are the patients with lupus and rheumatoid arthritis who take hydroxychloroquine daily to reduce swelling and rashes. Dr. Jeff Sparks says his patients at Brigham and Women's Hospital were already fretting about having enough medicine on hand if stores close or it's hard for them to go out. And then the president began calling the drug a game changer.

"The entire last week seemed to be filled with a lot of anxiety about what to do about medications, and in particular, patients asking for refills for hydroxychloroquine," Sparks says.

Some patients are already being told they can't get the medication or can only get a limited supply. The Lupus Foundation has asked congressional leaders to ensure supplies for lupus patients.

Sparks says hydroxychloroquine is what keeps many of his patients stable.

"So even if patients are doing well, stopping the medication could cause them to flare, which means that they then need to go on other immunosuppressants ... or even get admitted and potentially get exposed [to the coronavirus] in the clinical setting," Sparks says.

He added that hydroxychloroquine, like ventilators and masks, is a medical resource the country needs to learn to manage more carefully.

This story is part of a reporting partnership that includes WBUR, NPR and Kaiser Health News.

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