Hosted by Sandra Tsing Loh, The Loh Down on Science is a fun way to get your daily dose of science plus a dash of humor in less than two minutes.
Hosted by Sandra Tsing Loh
Airs Weekdays 2:31, 3:31 and 5:49 a.m.

How Do You Spell Zika?




Virology Blog

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One, two, three, It’s easy as … A-G-C?

This is Sandra Tsing Loh with the Loh Down on Science.

Who doesn’t love a spelling bee? Cute middle-schoolers lisping out words like Xanthosis and Logorrhea!

But spelling is vital inside living organisms too! Why?

See, cells need proteins to work properly. And these proteins are coded by molecules in a specific order. Like letters in a word. One letter out of place and the protein changes!

Zhiheng Xu at the Chinese Academy of Sciences studies Zika virus and microcephaly. That’s a condition where babies are born with a smaller than normal head. Mothers infected with Zika virus have more babies with microcephaly.

To study why, Xu teamed up with Cheng-Feng Qin [CHANG-fang CHEEN] from Beijing Institute of Microbiology and Epidemiology. They found that the protein code inside Zika has changed over a decade!

They concluded that these “spelling changes” make Zika MORE infectious. This could explain the epidemic of Zika-related microcephaly. But, if we can edit the infectious spelling error, we could halt the disease!

As any spelling bee champ knows -- one letter makes all the difference!