We try so hard to be perfect, to never make mistakes and to avoid failure at all costs. But mistakes happen. And when they do, how do we deal with being wrong? In this episode, TED speakers look at those darker moments in our lives, and consider why sometimes we need to make mistakes and face them head on. Dr. Brian Goldman tells a profound story about the first big mistake he made in the ER, and questions medicine's culture of denial. Professor Brené Brown explains how important it is to confront shame. Also, jazz composer Stefon Harris argues that a lot of our actions are seen as mistakes only because we don't react to them appropriately. Plus, Margaret Heffernan, the former CEO of five businesses, tells the story of two unexpected collaborators, and how good disagreement is central to progress.